This building began as a house and subsequently was enlarged and remodeled as a hotel. It was given a wraparound porch with bracketed piers and a slate-shingled mansard roof with gabled dormers. Nearby at 404 N. Main, the Belew-Harshman House began c. 1830 as a two-story frame, side-passage-plan building, and in 1890 acquired an octagonal tower and a porch with elaborate brackets. At 104 N. Main the Hisey-Mitchell building gained, c. 1890, a three-story hexagonal tower, a slate-shingled mansard roof with gabled dormers, and a wooden porch with an elaborate frieze. The building's northernmost section was constructed in 1881 as the C. P. Hisey Drugstore with a residence above.