The massive neon “Domino Sugars” sign on the roof of this refining plant is arguably one of Baltimore’s most recognizable icons and a symbol of this city’s historic importance in the sugar-processing industry. Built by the American Sugar Refining Company in one campaign and extending to the harbor on pilings, this sprawling plant was one of the largest sugar refineries in the United States for many decades. It featured a state-of-the-art pressure filtration system for purifying the liquefied sugar that allowed faster production with less labor than older gravity-fed systems. The complex comprises sixteen structures, including four reinforced-concrete processing buildings, offices, warehouses, and ancillary buildings. Currently the refinery continues to process about seven million pounds of sugar a day with about six hundred employees. An LED replica of the original neon sign was installed in 2021.