In continuous use since its construction as a store by Amplius Blake, this is among the finest extant Federal commercial buildings in the state. It is also part of a remarkable urban composition—one of a pair of granite-trimmed, brick, gable-front buildings with end chimneys tied by parapets that formed the western focus of the north village green. Its counterpart at 289 Main Street was reconstructed with large storefront windows after a fire in 1927. This store also boasts an arched granite panel above its recessed central door. It took its name from Amos Hood, who purchased the building for his drugstore in 1874. The shop interior, developed by one of his sons based on a drug store in Lowell, Massachusetts, remains largely intact. An external staircase leads to the second floor, occupied in Hood's day by a skylit photographic studio.