The eight- and eleven-story passenger station and general office building constructed by the Atchison, Topeka and Santa Fe Railway for its Texan subsidiary, the Gulf, Colorado and Santa Fe Railway (GC&SF) , closes the vista up Strand with architectural authority. In contrast to the ruddy coloration of the nineteenth-century buildings framing it, the Santa Fe Building gleams in a mantle of white glazed brick and terra-cotta. The symmetrical building is slightly off axis when viewed up Strand. This is because the central register and right (north) wing are additions to the left (south) wing, the latter having begun life as an addition to the preceding passenger terminal building of 1897. E. A. Harrison, the Santa Fe's Chicago-based corporate architect, cleverly pulled the complex together to form a new whole out of what had been disparate parts.

The Moody Foundation, the Galveston-based charitable foundation founded by the son of one of the GC&SF's original investors, W. L. Moody, bought the then-empty passenger station and office building in 1976 and retained Ford, Powell and Carson to rehabilitate it. Since 1982 it has housed the Galveston Railroad Museum.