One of the first buildings in Pittsburgh specifically designed for high-tech research was the Software Engineering Institute (SEI) (1987, Bohlin Powell Larkin Cywinski, and Burt Hill Kosar Rittelmann Associates; 4500 5th Avenue), a joint venture between Carnegie Mellon University and the Department of Defense. Its program called for a high-security environment, which dictated the building's three core elements: a public entrance pavilion, a controlled-access restricted office and laboratory block, and a parking garage. SEI is a neighbor to Mellon Institute (AL37) to the west and St. Paul Cathedral (AL36) across 5th Avenue to the northeast, with an exedra carved out of its facade picking up the axis of St. Paul Cathedral. The cathedral is reflected in SEI's glass curtain wall, whose two-tone vertical bands establish a secondary visual linkage with the giant colonnade of Mellon Institute. But there are limits to how self-effacing a large building can be, and SEI ultimately provides a cautionary tale of overcontextualization.

Two miles to the southwest, the office and research buildings on this forty-eight-acre riverside site had no such contextual demands when they were built. Their symbolism was almost palpable, since the shiny new structures were going up where the Eliza Furnaces of Jones and Laughlin (J&L) had stood for almost a century and a half. The complex remains significant and growing, in tribute to the competent manner in which Pittsburgh's Urban Redevelopment Authority (URA, a city-county agency) has nourished it. The development includes five buildings designed between 1990 and 2002 by Bohlin Cywinski Jackson and Burt Hill Kosar Rittelmann (later Burt Hill Architects) at 100, 200, 300, 550, and 700 Technology Drive. Bridgeside Point II (2007–2009; 450 Technology Drive) was designed by Dina F. Snider and John A. Martine for Strada, and Union Switch and Signal Research Center (1993–1995; 1000 Technology Drive) is by The Design Alliance Architects. True to their high-tech functions, the buildings look sleek and efficient with exterior surface materials of glass and metal panels. Still, to many Pittsburghers, the smoke-belching mills were a thrilling sight in contrast to the structures that replaced them. A Peter Eisenman design from the mid-1980s was originally intended for this site, but his deconstructivist recollection of the old J&L mills had spaces that were too eccentric to be rentable.

One important remnant of the river's industrial past near the Pittsburgh Technology Center (adjacent to 2nd Avenue and Bates Street) is the Hot Metal Bridge (c. 1887), which actually is two bridges with similar profiles sharing a set of stone piers. The upstream side held two tracks of the Monongahela Connecting Railroad; it was adapted in 2000 for automobile traffic. The downstream side held a single track underlain with metal plates protecting its wooden ties from sparks and the molten metal being shipped between the former steelmaking plant on one side of the river and the fabricating plant on the other. In 2007, it was adapted for bicycles and foot traffic.

In the North Hills, an innovative design for a similar high-tech company near I-79 at Warrendale (174-A Thornhill Road) was built for FORE Systems, Inc., in 1997, makers of ATM computer switches. As designed by Studios Architecture of San Francisco, the building distorts both perspective and form, leaving the viewer with a feeling of instability. The materials include brick with sides or ends of aluminum and glass in long three-story blocks. The high-tech, sleek character of this building in the suburbs outshines its cousins near the Monongahela River.